Asunción is a convenient center for Southern Cone air traffic. The international departure tax is US$16. There are only a few overland crossings: three from Argentina, two from Brazil and a difficult border crossing from Bolivia. From Asunción, a passenger boat takes irregular trips on the Río Paraguay to and from the Brazilian city of Corumbá.

Líneas Aéreas de Transporte Nacional (LATN) and Transporte Aéros del Mercosur (TAM), the airforce passenger service, have reasonably cheap flights to destinations in northern Paraguay and some parts of the Chaco. Bus services run frequently to most destinations around the country. Paraguay's antiquated, wood-burning trains are extremely cheap but sluggish, except for the 28km (17mi) line from Asunción to Areguá, on Lago Ypacaraí. Driving can be dangerous (especially at night), with wooden oxcarts and livestock among the more obvious road hazards. There are also passenger boats from Asunción up the Río Paraguay to a number of river ports. An extensive bus system and metered taxis operate in the capital.