Most travelers arrive from North America or the Caribbean, and less frequently from Venezuela (via Trinidad) and Suriname. There are no direct flights from Europe. The international departure tax is US$8. Overland crossings can be made to/from Brazil at the Lethem-Bomfin crossing point, but the border with Venezuela is closed. A passenger ferry crosses the Courantyne River at Corriverton (Springlands) to the Surinamese town of Nieuw Nickerie.

The recently privatized Guyana Air 2000 now flies from Georgetown to New York. As part of the deal, North American Airlines will offer reciprocal service from New York to Georgetown.

Guyana Airways has scheduled flights between Georgetown and Lethem plus a few other interior destinations. There's also several charter companies. Minibuses and collective taxis link Georgetown and most towns on the coastal belt. Guyana's road network, apart from a paved two-lane stretch from the capital to Linden, is poor and deters all but the hardiest of cyclists. With almost 1000km (620mi) of navigable river, Guyana has ferry services galore. Car hire is available in Georgetown and taxis are a must if crossing the city at night.